| Metabolomics Unveils Urinary Changes in Subjects with Metabolic Syndrome following 12-week Nuts Consumption. | |
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MedLine Citation:
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PMID: 21905751 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Through an HPLC-q-ToF-MS-driven non-targeted metabolomics approach, we aimed to discriminate changes in the urinary metabolome of subjects with metabolic syndrome (MetS), following 12 weeks of mixed nuts consumption (30g/day), compared to sex- and age-matched individuals given a control diet. The urinary metabolome corresponding to the nuts-enriched diet clearly clustered in a distinct group, and the multivariate data analysis discriminated relevant mass features in this separation. Metabolites corresponding to the discriminating ions (MS features) were then subjected to multiple tandem mass spectrometry experiments using LC-ITD-FT-MS, in order to confirm their putative identification. The metabolomics approach revealed 20 potential markers of nuts intake, including fatty acid conjugated metabolites, phase II and microbial-derived phenolic metabolites and serotonin metabolites. An increased excretion of serotonin metabolites was associated for the first time with nuts consumption. Additionally, the detection of urinary markers of gut microbial and phase II metabolism of nuts polyphenols confirmed the understanding of their bioavailability and bioactivity as a priority area of research in the determination of the health effects derived from nut consumption. The results confirmed how a non-targeted metabolomics strategy may help to access to unexplored metabolic pathways impacted by diet, thereby raising prospects for new intervention targets. |
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Authors:
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Sara Tulipani; Rafael Llorach; Olga Jáuregui; Patricia López-Uriarte; Mar Garcia-Aloy; Mònica Bullo; Jordi Salas-Salvadó; Cristina Andrés-Lacueva |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-12 |
Journal Detail:
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Title: Journal of proteome research Volume: - ISSN: 1535-3907 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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