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Metabolomics and First Trimester Prediction of Early-Onset Preeclampsia.
MedLine Citation:
PMID:  22494326     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To evaluate the use of metabolomics for the first-trimester detection of maternal metabolic dysfunction in and prediction of subsequent development of early-onset preeclampsia. Study Design: This was a case-control study of maternal plasma samples collected at 11-13 weeks' gestation from 30 women that subsequently developed preeclampsia requiring delivery before 34 weeks and 60 unaffected controls. Nuclear magnetic Resonance (NMR) spectroscopy was used to identify and quantify metabolomic changes in cases versus controls. Both genetic computing and standard statistical analyses were performed to predict the development of preeclampsia from the metabolite concentrations alone as well as the combination of metabolite concentrations with maternal characteristics and first trimester uterine artery Doppler pulsatility index (PI). Results: Significant differences between cases and controls were found for 20 metabolites. A combination of four of these metabolites (citrate, glycerol, hydroxy-isovalerate and methionine) appeared highly predictive of preeclampsia with an estimated detection rate of 75.9%, at a false positive rate of 4.9%. The predictive performance was improved by the addition of uterine artery Doppler PI and fetal crown rump length (CRL) and with an estimated detection rate of 82.6%, at a false positive rate of 1.6%. Conclusion: A profound change in the first-trimester metabolite profile was noted in women that subsequently developed early-onset preeclampsia. Preliminary algorithms appeared highly sensitive for first-trimester prediction of preeclampsia.
Authors:
Ray O Bahado-Singh; Ranjit Akolekar; Rupasri Mandal; Edison Dong; Jianguo Xia; Michael Kruger; David S Wishart; Kypros Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-12
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Wayne State University, MI, USA.
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