| Metabolomic Study of Interactive Effects of Phenol, Furfural, and Acetic Acid on Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 21978393 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Metabolic profiling was carried out to investigate the interactive effects of three representative inhibitors (furfural, phenol, and acetic acid) in lignocellulosic hydrolysate on Saccharomyces cerevisiae during ethanol fermentation. Our results revealed that three inhibitors exhibited significantly synergistic effects on the growth, fermentation, and some metabolites of yeast. Acetic acid exerted the most severe effects on yeast in the combination of three inhibitors, enhancing amino acids metabolism and inhibiting central carbon metabolism. The effects on yeast cells by acetic acid were enhanced by the presence of phenol and furfural, which might be owing to the loss of membrane integrity and the inhibition on metabolism. Further investigation indicated that the combination of inhibitors also exhibited antagonistic effects mainly on threonine, cadaverine, inositol, and tryptophan, weakening or reversing the effects of individual inhibitor. It might be due to the more severe damage by the combined inhibitors, and different repairing mechanism of cells in the presence of individual and combined inhibitors. Better understanding of the synergistic and antagonistic effects of the inhibitors will be helpful for the improvement of tolerant strains and the optimization of lignocellulosic fermentation. |
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Authors:
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Ming-Zhu Ding; Xin Wang; Yang Yang; Ying-Jin Yuan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Omics : a journal of integrative biology Volume: 15 ISSN: 1557-8100 ISO Abbreviation: OMICS Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101131135 Medline TA: OMICS Country: United States |
Other Details:
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Languages: eng Pagination: 647-53 Citation Subset: IM |
Affiliation:
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Key Laboratory of Systems Bioengineering (Tianjin University), Ministry of Education; Department of Pharmaceutical Engineering, School of Chemical Engineering & Technology, Tianjin University , Tianjin, People's Republic of China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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