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Metabolomic Phenotyping Validates The Infant Rhesus Monkey As A Model of Human Infant Metabolism.
MedLine Citation:
PMID:  23201704     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: Rhesus macaque monkeys are widely used as models for human physiology and behavior. They are particularly suited for studies on infant nutrition and metabolism; however, few studies have directly compared their metabolic or microbiological phenotypes. The aim of this study was to compare the metabolomic profiles and microbiome of milk from human and rhesus mothers, and the metabolomic profiles of urine and serum from human and rhesus infants in order to establish the value of this model for human nutrition research. METHODS:: Milk samples were collected from rhesus and human mothers at similar stages of lactation. Urine and serum samples were collected from breast-fed rhesus and human infants. H NMR spectra were acquired for all samples and metabolites were identified and quantified using targeted profiling techniques. The microbial community structure of milk was examined using16S rRNA gene sequencing. RESULTS:: An identical set of metabolites was identified in the urine and serum profiles from human and rhesus infants. In urine, 65% of the metabolites were present in similar concentrations while ∼40% were similar in serum. The gross composition of human and rhesus milk was comparable, including the overall microbial community at both the phylum and order level; however, some oligosaccharides found in human milk were not present in monkey milk. CONCLUSIONS:: Comparison of the milk microbiome and urine, serum and milk metabolome of rhesus macaques and humans has revealed substantial similarities that provide unique biological information highlighting the significance of rhesus macaques as a model for infant nutrition and developmental research.
Aifric Oʼsullivan; Xuan He; Elizabeth M S McNiven; Katie Hinde; Neill W Haggarty; Bo Lönnerdal; Carolyn M Slupsky
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Department of Food Science and Technology †Department of Nutrition, University of California, Davis, CA, USA ‡Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA §Brain, Mind, & Behavior Unit, California National Primate Research Center, Davis CA, USA ||Fonterra Ingredients Innovation, Fonterra Co-operative Group, Palmerston North, New Zealand.
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