| Metabolomic Analysis for First-Trimester Down Syndrome Prediction. | |
MedLine Citation:
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PMID: 23313728 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To perform first trimester maternal serum metabolomic analysis and compare results in aneuploid versus Down syndrome (DS) pregnancies. STUDY DESIGN: This was a case control study of pregnancies between 11+0 and 13+6 weeks. There were 30 DS cases and 60 controls in which first trimester maternal serum was analyzed. NMR based metabolomic analysis was performed for DS prediction. RESULTS: Concentrations of 11 metabolites were significantly different in the serum of DS pregnancies. The combination of 3-hydroxyisovalerate, 3-hydroxybuterate, and maternal age had a 51.9% sensitivity at 1.9% false positive rate for DS detection. One multi-marker algorithm had 70% sensitivity at 1.7% false positive rate. Novel markers such as 3-hydroxybutyrate, involved in brain growth and myelination, and 2-hydroxybutyrate involved in the defense against oxidative stress, were found to be abnormal. CONCLUSION: The study reports novel metabolomic markers for the first trimester prediction of fetal DS. Metabolomics provided insights into the cellular dysfunction in DS. |
Authors:
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Ray O Bahado-Singh; Ranjit Akolekar; Rupasri Mandal; Edison Dong; Jianguo Xia; Michael Kruger; David S Wishart; Kypros Nicolaides |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-8 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Wayne State University, MI, USA. Electronic address: rbahados@med.wayne.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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