Document Detail


Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey.
MedLine Citation:
PMID:  23269483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency anemia affects many pregnant women and young infants worldwide. The health impact is significant, given iron's known role in many body functions, including oxidative and lipid metabolism, protein synthesis and brain neurochemistry. The following research determined if (1)H NMR spectroscopy-based metabolomic analysis of cerebrospinal fluid (CSF) could detect the adverse influence of early life iron deficiency on the central nervous system. Using a controlled dietary model in 43 infant primates, distinct differences were found in spectra acquired at 600 MHz from the CSF of anemic monkeys. Three metabolite ratios, citrate/pyruvate, citrate/lactate and pyruvate/glutamine ratios, differed significantly in the iron deficient infant and then normalized following the consumption of dietary iron and improvement of clinical indices of anemia in the heme compartment. This distinctive metabolomic profile associated with anemia in the young infant indicates that CSF can be employed to track the neurological effects of iron deficiency and benefits of iron supplementation.
Authors:
Raghavendra Rao; Kathleen Ennis; Gulin Oz; Gabriele R Lubach; Michael K Georgieff; Christopher L Coe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-28
Journal Detail:
Title:  Neurochemical research     Volume:  38     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-08-15     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / blood,  cerebrospinal fluid*
Animals
Brain / metabolism*
Citric Acid / cerebrospinal fluid
Energy Metabolism*
Female
Glutamine / cerebrospinal fluid
Iron / deficiency*
Lactic Acid / cerebrospinal fluid
Macaca mulatta / growth & development
Magnetic Resonance Imaging
Metabolomics*
Pyruvic Acid / cerebrospinal fluid
Grant Support
ID/Acronym/Agency:
P01 HD039386/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS; R01 HD029421/HD/NICHD NIH HHS; R01 HD057064/HD/NICHD NIH HHS; R01 HD057064/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0RH81L854J/Glutamine; 2968PHW8QP/Citric Acid; 33X04XA5AT/Lactic Acid; 8558G7RUTR/Pyruvic Acid; E1UOL152H7/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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