Document Detail

Metabolites of the aminoacetone pathway in blood after exercise.
MedLine Citation:
PMID:  7453570     Owner:  NLM     Status:  MEDLINE    
The following article reports (A) data on glyoxalase I activity in skeletal muscle of untrained men and endurance--trained athletes, and (B) the presence at rest and the rise in blood after exercise of two metabolites of the aminoacetone pathway of amino acid degradation in man. Glyoxalase I showed an average activity of 191 +/- 38 U/g wet weight (37 degrees C) in bioptic samples of m.vastus medialis quadricipitis of young adults whereas this was of 235 +/- 64 U/g (p < 0.15) in athletes. After an ergometer exercise test with increasing intensity (50 to 400 Watt (W), 3 min-steps) by well trained cyclists, blood (L-(+)-lactate increased to 10.12 mmole/liter, whereas methylglyoxal rose by 48.4% and D-(-)-lactate by 70% (resting levels 92 and 100/mumole/liter, respectively). The possible physiologic significance of the assumed aminoacetone pathway was discussed with respect to muscular activity.
G Haralambie; M Mössinger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  29     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1258-61     Citation Subset:  IM; S    
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MeSH Terms
Acetone / analogs & derivatives*,  metabolism
Amino Acids / metabolism*
Lactates / blood
Lactoylglutathione Lyase / metabolism*
Lyases / metabolism*
Muscles / enzymology
Physical Exertion*
Pyruvaldehyde / blood
Reg. No./Substance:
0/Amino Acids; 0/Lactates; 298-08-8/aminoacetone; 67-64-1/Acetone; 78-98-8/Pyruvaldehyde; EC 4.-/Lyases; EC Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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