| Metabolites of 2,4',5-trichlorobiphenyl in rats. | |
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MedLine Citation:
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PMID: 6419479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nineteen metabolites of 2,4',5-trichlorobiphenyl were isolated from rat urine, faeces and bile. These metabolites resulted from one or more of the following transformations: dechlorination, hydroxylation, thiolation, methylthiolation, methylthio oxidation, dihydrodiol formation, mercapturic acid formation and conjugation with glucuronic acid. Mercapturic acid-pathway metabolites were the major metabolites in the bile. Methylthio-, methylsulphinyl- and methylsulphonyl-containing metabolites were the major metabolites in the faeces of control rats. A synthetic pathway for the preparation of sulphur-containing metabolites of trichlorobiphenyl is described. |
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Authors:
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J E Bakke; V J Feil; A Bergman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 13 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1984-02-15 Completed Date: 1984-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 555-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Biotransformation Feces / analysis Male Mass Spectrometry Polychlorinated Biphenyls / metabolism*, urine Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Polychlorinated Biphenyls; 16606-02-3/2,4',5-trichlorobiphenyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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