Document Detail


Metabolites of 2,4',5-trichlorobiphenyl in rats.
MedLine Citation:
PMID:  6419479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nineteen metabolites of 2,4',5-trichlorobiphenyl were isolated from rat urine, faeces and bile. These metabolites resulted from one or more of the following transformations: dechlorination, hydroxylation, thiolation, methylthiolation, methylthio oxidation, dihydrodiol formation, mercapturic acid formation and conjugation with glucuronic acid. Mercapturic acid-pathway metabolites were the major metabolites in the bile. Methylthio-, methylsulphinyl- and methylsulphonyl-containing metabolites were the major metabolites in the faeces of control rats. A synthetic pathway for the preparation of sulphur-containing metabolites of trichlorobiphenyl is described.
Authors:
J E Bakke; V J Feil; A Bergman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  13     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1984-02-15     Completed Date:  1984-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / metabolism
Biotransformation
Feces / analysis
Male
Mass Spectrometry
Polychlorinated Biphenyls / metabolism*,  urine
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Polychlorinated Biphenyls; 16606-02-3/2,4',5-trichlorobiphenyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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