Document Detail


Metabolite transport across the peroxisomal membrane.
MedLine Citation:
PMID:  17173541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, much progress has been made with respect to the unravelling of the functions of peroxisomes in metabolism, and it is now well established that peroxisomes are indispensable organelles, especially in higher eukaryotes. Peroxisomes catalyse a number of essential metabolic functions including fatty acid beta-oxidation, ether phospholipid biosynthesis, fatty acid alpha-oxidation and glyoxylate detoxification. The involvement of peroxisomes in these metabolic pathways necessitates the transport of metabolites in and out of peroxisomes. Recently, considerable progress has been made in the characterization of metabolite transport across the peroxisomal membrane. Peroxisomes posses several specialized transport systems to transport metabolites. This is exemplified by the identification of a specific transporter for adenine nucleotides and several half-ABC (ATP-binding cassette) transporters which may be present as hetero- and homo-dimers. The nature of the substrates handled by the different ABC transporters is less clear. In this review we will describe the current state of knowledge of the permeability properties of the peroxisomal membrane.
Authors:
Wouter F Visser; Carlo W T van Roermund; Lodewijk Ijlst; Hans R Waterham; Ronald J A Wanders
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Biochemical journal     Volume:  401     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-01-16     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-75     Citation Subset:  IM    
Affiliation:
University of Amsterdam, Academic Medical Centre, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, F0-224, Meibergdreef 9, Amsterdam, 1105 AZ The Netherlands. w.f.visser@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / physiology*
Amino Acid Transport Systems, Neutral / metabolism
Animals
Arabidopsis Proteins / metabolism
Calcium-Binding Proteins / metabolism
Calcium-Transporting ATPases / metabolism
Fatty Acids / metabolism*
Fatty Acids, Nonesterified / metabolism
Humans
Hydrogen-Ion Concentration
Intracellular Membranes / metabolism*
Membrane Proteins / metabolism
Molecular Chaperones / metabolism
NAD / metabolism
NADP / metabolism
Peroxisomes / metabolism*
Plants / metabolism
Porins / physiology
Saccharomyces cerevisiae Proteins / metabolism
Chemical
Reg. No./Substance:
0/ANT1 protein, Arabidopsis; 0/ATP-Binding Cassette Transporters; 0/Amino Acid Transport Systems, Neutral; 0/Arabidopsis Proteins; 0/Calcium-Binding Proteins; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Membrane Proteins; 0/Molecular Chaperones; 0/PEX11 protein, S cerevisiae; 0/PXMP2 protein, human; 0/PXMP4 protein, human; 0/Porins; 0/Saccharomyces cerevisiae Proteins; 0/peroxisomal membrane protein 34; 53-59-8/NADP; 53-84-9/NAD; EC 3.6.1.8/Calcium-Transporting ATPases; EC 3.6.3.8/SSC1 protein, S cerevisiae
Comments/Corrections

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