| Metabolite changes in aged muscle during stimulation. | |
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MedLine Citation:
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PMID: 6699373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolite concentrations of adenosine-5'-phosphate, phosphocreatine, and lactate were compared in adult and aged rat soleus and superficial, medial and deep, lateral gastrocnemius muscles after 3 min of moderate or intense stimulation in situ. The concentration of phosphocreatine in all muscles progressively decreased as contractile frequency increased. In most muscles, lactate increased coincident with greater contractile frequency. These changes were greater in aged muscles. Decreases in the concentration of adenosine-5'-phosphate with stimulation, where evident, were also greater in aged muscles. Metabolite levels in nonstimulated muscles were effected minimally by age. The cytochrome-c concentration was reduced with age in each muscle section. The results indicate that aged skeletal muscle has a lesser ability than adult skeletal muscle to maintain energy balance during contraction. |
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Authors:
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G A Dudley; S J Fleck |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of gerontology Volume: 39 ISSN: 0022-1422 ISO Abbreviation: J Gerontol Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-04-18 Completed Date: 1984-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374762 Medline TA: J Gerontol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Age Factors Animals Hindlimb Isometric Contraction Lactates / metabolism Lactic Acid Male Muscle Contraction* Muscles / metabolism* Phosphocreatine / metabolism Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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