Document Detail


Metabolism of totally ischemic excised dog heart. I. Construction of a computer model.
MedLine Citation:
PMID:  40439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Construction and fit to the experimental data of a computer model of glycolysis, the Krebs cycle, and related metabolism in an ischemic dog heart preparation, involving 122 metabolites, 65 enzymes, and 406 chemical reactions, is described. The experimental preparation simulated is a dog heart excised from the body, placed in a beaker of Tyrode's solution, and sampled for 100 min; the model required only moderate modification from models representing perfused rat hearts, and little modification from a model of another ischemic dog heart preparation. Common underlying mechanisms for the ischemia are indicated, although this preparation appears to evolve more slowly with time, perhpas owing to heavy sedation and diffusion-limited transport. Lactate is, at first, exported and then accumulates intracellularly; pH falls, but not as much in the mitochondria as the cytoplasm; redox couples go reduced, but with counterintuitive time courses; calcium phosphate is calculated to precipitate, as often observed in cardiac ischemia.
Authors:
M J Achs; D Garfinkel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  318-26     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adenine Nucleotides / metabolism
Animals
Computers*
Coronary Disease / metabolism*
Dogs
Glycogen / metabolism*
Glycolysis*
Hydrogen-Ion Concentration
Kinetics
Mitochondria, Heart / metabolism
Models, Biological
Myocardium / metabolism*
NAD / metabolism
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 53-84-9/NAD; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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