Document Detail


Metabolism of synthetic surfactants.
MedLine Citation:
PMID:  8131363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article provided a brief overview of synthetic surfactants and DPPC metabolism, and summarized disposition data on the most widely used synthetic surfactant, CPHT (colfosceril palmitate, hexadecanol, and tyloxapol; Exosurf Neonatal, Burroughs Wellcome Co.). In separate experiments, young male rabbits were given intratracheal administrations of CPHT trace-labeled with either hexadecanol-3-[14C], choline-labeled [14C]DPPC, or [3H]tyloxapol. In mass balance and tissue distribution studies, radioactivity was quantitated in excreta and selected tissues over 5 days. Hexadecanol entered the pathways of intermediary lipid metabolism, via oxidation to palmitic acid, which was then utilized in the synthesis of phospholipids. After 5 days, most of the radiolabeled dose (56%) was distributed throughout the body, with renal (4%) and fecal (2%) excretion being minor routes of elimination compared with expired air (28%). The active component, DPPC, was still retained by the body (72%) after 5 days, having entered the pathways of lipid metabolism to become tissue associated. At this time, the lung and liver each contained approximately 10% of the labeled dose, whereas elimination in excreta (8%) was minimal compared with that in expired air (17%). Tyloxapol and metabolites were retained by the lung, released slowly (t1/2 = 5 to 6 days) into the systemic circulation, and eliminated through fecal (27%) and renal (26%) excretion.
Authors:
R L DeAngelis; J W Findlay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  20     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-21     Completed Date:  1994-04-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-710     Citation Subset:  IM    
Affiliation:
Department of Bioanalytical Chemistry/Metabolism, Burroughs Wellcome Co., Research Triangle Park, North Carolina.
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MeSH Terms
Descriptor/Qualifier:
1,2-Dipalmitoylphosphatidylcholine / analogs & derivatives,  metabolism
Animals
Fatty Alcohols / metabolism
Metabolic Clearance Rate
Polyethylene Glycols / metabolism
Pulmonary Surfactants / chemical synthesis,  metabolism*,  pharmacokinetics
Surface-Active Agents / metabolism
Chemical
Reg. No./Substance:
0/Fatty Alcohols; 0/Polyethylene Glycols; 0/Pulmonary Surfactants; 0/Surface-Active Agents; 25301-02-4/tyloxapol; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 36653-82-4/cetyl alcohol; 63-89-8/colfosceril palmitate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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