| Metabolism of synthetic human heptadecapeptide gastrin by the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 653519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthetic human heptadecapeptide gastrin-1 (SHG-17-1) and rat insulin were perfused cyclically through the isolated rat liver in a plasma-free medium. Synthetic human gastrin did not disappear from the medium at either physiological or supraphysiological levels, whereas rat insulin was cleared rapidly. Chromatography of perfusion samples showed that the SHG-17-U was neither lysed to smaller peptides nor changed to the larger molecular weight species. The isolated rat liver apparently plays no role in the metabolism of synthetic human heptadecapeptide gastrin-I. |
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Authors:
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H Sacks; B J Grant; A I Vinik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 53 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-07-15 Completed Date: 1978-07-15 Revised Date: 2004-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 249-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Gastrins / metabolism* Insulin / metabolism Liver / metabolism* Male Perfusion Rats |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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