| Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. | |
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MedLine Citation:
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PMID: 20803026 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and MR spectroscopy are thought to differentiate tumefactive autoimmune inflammatory demyelinating lesions from glial brain tumours. The aim of this work is to evaluate whether regional cerebral blood volume (rCBV), as well as choline (Cho), N-acetyl-aspartate (NAA) and myo-inositol (mIns) concentrations differ between tumefactive lesions and World Health Organization (WHO) grade II-III gliomas. Five patients with single autoimmune inflammatory demyelinating lesions and nine patients with WHO grade II and III gliomas were examined by DSC-MRI and by two-dimensional (2D) (1)H MR spectroscopic imaging ((1)H-MRSI). rCBV values and metabolite concentrations were normalised to the respective values of the contralateral hemisphere. Normalised rCBV in the tumefactive lesions (mean 2.89, range 1.98-6.74) was in the some high level as in gliomas (mean 2.77, range 1.43-6.22). (1)H-MRSI revealed increased normalised choline concentrations in five of six examinations of autoimmune lesions (mean 1.4, range 1.06-1.8) and in eight of nine gliomas (mean 1.35, range 0.92-1.73). Tumefactive autoimmune inflammatory demyelinating lesions not only have imaging appearance of gliomas but may also imitate marked increase of rCBV and Cho in WHO grade II-III gliomas. |
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Authors:
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Stella Blasel; Waltraud Pfeilschifter; Viola Jansen; Klaus Mueller; Friedhelm Zanella; Elke Hattingen |
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Publication Detail:
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Type: Journal Article Date: 2010-08-28 |
Journal Detail:
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Title: Journal of neurology Volume: 258 ISSN: 1432-1459 ISO Abbreviation: J. Neurol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 113-22 Citation Subset: IM |
Affiliation:
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Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany, Stella.Blasel@kgu.de. |
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