Document Detail


Metabolism of red blood cells in chronic renal failure. I. Glycolytic enzyme levels.
MedLine Citation:
PMID:  226898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper starts a series on red blood cell (RBC) metabolism in patients with chronic renal failure (CRF). The glycolytic enzyme levels and in vitro half-lives of these patients' RBCs were determined. A number of enzymes (hexokinase, glucose-6-phosphate isomerase, fructose-6-phosphate kinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase) showed higher activities than in normal control RBCs. Other enzyme activities were normal. These results were discussed and several possible mechanisms considered. We favour the point of view of a shortened life span of the RBCs in CRF, making the most unstable enzymes of the glycolytic sequence appear increase as compared with normal controls.
Authors:
J L Rodríguez-Commes; J M Tabernero; P Martin-Vasallo; S De Castro; E Battaner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  24     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1979  
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Erythrocytes / enzymology*
Female
Fructose-Bisphosphate Aldolase / blood
Fructosephosphates / blood
Glucose-6-Phosphate Isomerase / blood
Glyceraldehyde-3-Phosphate Dehydrogenases / blood
Hexokinase / blood
Humans
Kidney Failure, Chronic / enzymology*,  therapy
L-Lactate Dehydrogenase / blood
Male
Middle Aged
Phosphofructokinase-1 / blood
Phosphoglycerate Kinase / blood
Phosphoglycerate Mutase / blood
Phosphopyruvate Hydratase / blood
Pyruvate Kinase / blood
Renal Dialysis
Triose-Phosphate Isomerase / blood
Chemical
Reg. No./Substance:
0/Fructosephosphates; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC 2.7.1.1/Hexokinase; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.1.40/Pyruvate Kinase; EC 2.7.2.3/Phosphoglycerate Kinase; EC 4.1.2.13/Fructose-Bisphosphate Aldolase; EC 4.2.1.11/Phosphopyruvate Hydratase; EC 5.3.1.1/Triose-Phosphate Isomerase; EC 5.3.1.9/Glucose-6-Phosphate Isomerase; EC 5.4.2.1/Phosphoglycerate Mutase

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