| Metabolism and proliferation share common regulatory pathways in cancer cells. | |
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MedLine Citation:
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PMID: 20514019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer development involves major alterations in cells' metabolism. Enhanced glycolysis and de novo fatty acids synthesis are indeed characteristic features of cancer. Cell proliferation and metabolism are tightly linked cellular processes. Others and we have previously shown a close relationship between metabolic responses and proliferative stimuli. In addition to trigger proliferative and survival signaling pathways, most oncoproteins also trigger metabolic changes to transform the cell. We present herein the view that participation of cell-cycle regulators and oncogenic proteins to cancer development extend beyond the control of cell proliferation, and discuss how these new functions may be implicated in metabolic alterations concomitant to the pathogenesis of human cancers. |
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Authors:
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V Fritz; L Fajas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-05-31 |
Journal Detail:
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Title: Oncogene Volume: 29 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-07 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 4369-77 Citation Subset: IM |
Affiliation:
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Institut de Recherche en Cancérologie de Montpellier, Montpellier, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology Cell Proliferation* Humans Lipid Metabolism / physiology Models, Biological Neoplasms / metabolism*, pathology*, physiopathology Signal Transduction / genetics, physiology* Transcription Factors / metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors |
| Comments/Corrections | |
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