| Metabolism of phytoestrogen conjugates. | |
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MedLine Citation:
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PMID: 16399358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phytoestrogens are plant-derived compounds with physiologic estrogenic effects. They are present in the plant as glycosidic conjugates, some of which contain further chemical modifications (acetate, malonate, and 3-hydroxy-3-methylglutarate esters and 2,3-dihydroxysuccinate ether). In the gastrointestinal tract, the conjugates undergo hydrolysis catalyzed by enzymes in the intestinal wall and by gut bacteria. On entering the systemic circulation, the phytoestrogens may undergo extensive metabolism to other compounds through reactions involving demethylation, methylation, hydroxylation, chlorination, iodination, and nitration. In addition, all these compounds can undergo conjugation to form beta-glucuronides and sulfate esters. This chapter describes the methods of analysis of all these compounds, the sources of or methods to manufacture suitable standards, and the procedures for examining the enzymes that catalyze these reactions. |
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Authors:
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Tracy L D'Alessandro; Brenda J Boersma-Maland; T Greg Peterson; Jeff Sfakianos; Jeevan K Prasain; Rakesh P Patel; Victor M Darley-Usmar; Nigel P Botting; Stephen Barnes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Methods in enzymology Volume: 400 ISSN: 0076-6879 ISO Abbreviation: Meth. Enzymol. Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-09 Completed Date: 2006-02-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0212271 Medline TA: Methods Enzymol Country: United States |
Other Details:
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Languages: eng Pagination: 316-42 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Alabama at Birmingham, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Chemical Fractionation / methods Chromatography, High Pressure Liquid Dietary Supplements / analysis Food Analysis Hydrolysis Isoflavones / chemistry Lignans / chemistry Phytoestrogens / analysis*, metabolism*, standards Reverse Transcriptase Polymerase Chain Reaction Solvents Soybeans / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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1 P50 AT-00477/AT/NCCAM NIH HHS; 1 R01 CA61668/CA/NCI NIH HHS; 1 S10 RR 06487/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Lignans; 0/Phytoestrogens; 0/Solvents |
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