Document Detail

Metabolism of perorally administered xylitol in rat tissues.
MedLine Citation:
PMID:  7452365     Owner:  NLM     Status:  MEDLINE    
Rats were given xylitol (X) or glucose (G) in drinking water for a period of 28-33 days of which the last 2 days also comprised intake of 14C(U)-X or -G. Samples of plasma, liver, kidneys, pancreas, duodenum and the parotid, submandibular and lacrimal glands were homogenized and separated into various fractions for radioactivity and chemical analyses. The X-fed animals had smaller lacrimal and submandibular glands than the G-fed siblings. The radioactivities of the plasma, liver and kidney trichloroacetic acid extracts of both sexes increased more in the X-groups. X increased the incorporation of the label into the total lipids of plasma, liver and duodenum in both sexes. In males, X increased the labeling of both the neutral lipids and phospholipids. In females, X increased plasma lysolecithin and decreased plasma lecithin. The organs of the X-fed females contained less ascorbic acid than those of the G-fed animals, except for plasma and the parotid glands. Several organs of the males also showed this phenomenon. X and G thus exerted selective effects on the exocrine glands. Although X entered easily the regular G metabolism and acted as a physiological carbon source, the incorporation of labeled X was, however, sex-dependent. The relationship between peroral xylitol and the metabolism of phospholipids and ascorbic acid should be especially considered in rats.
M M Hämäläinen; K K Mäkinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  111     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-22     Citation Subset:  IM    
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MeSH Terms
Exocrine Glands / anatomy & histology,  metabolism*
Glucose / metabolism*
Lipid Metabolism*
Organ Size / drug effects
Pancreas / metabolism
Phospholipids / metabolism
Salivary Glands / metabolism
Sex Factors
Tissue Distribution
Xylitol / administration & dosage,  metabolism*
Reg. No./Substance:
0/Phospholipids; 50-99-7/Glucose; 87-99-0/Xylitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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