Document Detail


Metabolism of peptide drugs by the microorganisms in rat cecal contents.
MedLine Citation:
PMID:  7550138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery.
Authors:
H Tozaki; Y Emi; E Horisaka; T Fujita; A Yamamoto; S Muranishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  18     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  929-31     Citation Subset:  IM    
Affiliation:
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcitonin / metabolism
Cecum / metabolism,  microbiology*
Half-Life
Insulin / metabolism
Peptides / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Peptides; 11061-68-0/Insulin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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