Document Detail

Metabolism of peptide drugs by the microorganisms in rat cecal contents.
MedLine Citation:
PMID:  7550138     Owner:  NLM     Status:  MEDLINE    
The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery.
H Tozaki; Y Emi; E Horisaka; T Fujita; A Yamamoto; S Muranishi
Related Documents :
19766178 - The influence of polymer architecture on the protective effect of novel comb shaped amp...
24652948 - Uric acid induces endothelial dysfunction by vascular insulin resistance associated wit...
18164928 - Characterization of drug-chitosan interaction by 1h nmr, ftir and isothermal titration ...
11225658 - Preliminary study of oral polylactide microcapsulated insulin in vitro and in vivo.
334138 - Control of blood glucose in diabetics using an artificial pancreas.
19528368 - Efficacy of a continuous glp-1 infusion compared with a structured insulin infusion pro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  18     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  929-31     Citation Subset:  IM    
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcitonin / metabolism
Cecum / metabolism,  microbiology*
Insulin / metabolism
Peptides / metabolism*
Reg. No./Substance:
0/Peptides; 11061-68-0/Insulin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  9-Hydroxymethyl-10-carbamoylacridan in human serum is one of the major metabolites of carbamazepine.
Next Document:  Long-term G loads (+Gz) and the prediction of their tolerance