| Metabolism of peptide drugs by the microorganisms in rat cecal contents. | |
| | |
MedLine Citation:
|
PMID: 7550138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also rapidly degraded in supernatant, while we found few degradation products of insulin. These findings suggest that care should be taken to metabolize the peptide drugs by microorganisms when they are administered to the large intestine for colon-specific drug delivery. |
| | |
Authors:
|
H Tozaki; Y Emi; E Horisaka; T Fujita; A Yamamoto; S Muranishi |
Related Documents
:
|
19766178 - The influence of polymer architecture on the protective effect of novel comb shaped amp... 18164928 - Characterization of drug-chitosan interaction by 1h nmr, ftir and isothermal titration ... 11225658 - Preliminary study of oral polylactide microcapsulated insulin in vitro and in vivo. 23278488 - Microalbuminuria: a neglected cardiovascular risk factor in non-diabetic individuals? 334138 - Control of blood glucose in diabetics using an artificial pancreas. 19528368 - Efficacy of a continuous glp-1 infusion compared with a structured insulin infusion pro... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biological & pharmaceutical bulletin Volume: 18 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 1995 Jun |
Date Detail:
|
Created Date: 1995-11-20 Completed Date: 1995-11-20 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 929-31 Citation Subset: IM |
Affiliation:
|
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcitonin / metabolism Cecum / metabolism, microbiology* Half-Life Insulin / metabolism Peptides / metabolism* Rats |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 11061-68-0/Insulin; 9007-12-9/Calcitonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 9-Hydroxymethyl-10-carbamoylacridan in human serum is one of the major metabolites of carbamazepine.
Next Document: Long-term G loads (+Gz) and the prediction of their tolerance