| Metabolism of the pancreatic carcinogen N-nitroso-bis(2-oxopropyl)amine after oral and intraperitoneal administration to Syrian golden hamsters. | |
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MedLine Citation:
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PMID: 633398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of N-nitroso-bis(2-oxopropyl)amine (BOP) and its metabolites in the urine, blood, bile, and pancreatic juice were compared after ip and oral administration of BOP to Syrian golden hamsters to explain the differing organotropic tumor spectra resulting from treatment by these two routes. The levels of BOP and its metabolites N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) and N-nitroso-bis(2-hydroxypropyl)amine in the urine, blood, bile, and pancreatic juice were generally less after oral administration than after ip administration. The results suggested that HPOP may be a proximate pancreatic carcinogen in hamsters administered BOP, inasmuch as it was the major metabolite in the blood and pancreatic juice after ip administration. However, the results did not indicate a mechanism for the increased incidence of bile duct tumors that after oral administration of BOP. |
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Authors:
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R Gingell; P Pour |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 60 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1978 Apr |
Date Detail:
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Created Date: 1978-05-20 Completed Date: 1978-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 911-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bile / metabolism* Bile Duct Neoplasms / chemically induced Cricetinae Injections, Intraperitoneal Male Mesocricetus Neoplasms, Experimental / chemically induced Nitrosamines / administration & dosage, metabolism* Pancreatic Ducts Pancreatic Juice / metabolism* Pancreatic Neoplasms / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Nitrosamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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