Document Detail

Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat.
MedLine Citation:
PMID:  3922425     Owner:  NLM     Status:  MEDLINE    
Essential fatty acids are absolutely necessary for maintaining the proper condition of the water barrier (stratum compactum) in the skin. Even direct topical application of linoleic acid or any other Z,Z-(n-6, n-9)-fatty acid to the skin restores the barrier in essential fatty acid-deficient animals. In order to investigate the mechanism by which these polyunsaturated fatty acids exert their activity, radioactively labelled fatty acids were applied to the skin of the live animal and the epidermal lipids were analysed after 1-4 days. Much radioactivity was incorporated into two peculiar lipids, viz. acyl ceramide and acyl acid, which are characteristic of the barrier, in which linoleate was esterified to the end-position of very-long-chain (C30-34) unsaturated omega-hydroxy fatty acids. Strong evidence was obtained which showed that these lipids carry linoleate into the barrier layer where it is converted, probably by lipoxygenase(s), into a series of peroxidated lipids. The lipoxygenase inhibitor, eicosatetraynoic acid, prevents both oxygenation of the polyunsaturated fatty acid and the formation of a healthy skin. This peroxidation may supply the mediators which induce the proper differentiation of the epidermal cells into an effective stratum compactum and a horny layer.
D H Nugteren; E Christ-Hazelhof; A van der Beek; U M Houtsmuller
Related Documents :
7415805 - Lipids in the liver and kidney of rats, fed various heavy metals.
17805885 - Fatty acid metabolism in the chloroplast lipids of green and blue-green algae.
14043995 - Fatty acid composition of lipids from streptococcus cremoris and streptococcus lactis v...
16866345 - A faah-regulated class of n-acyl taurines that activates trp ion channels.
12420875 - Synthesis of n-arylsulfonyl dl-phenylserine derivatives exhibiting anti-inflammatory ac...
4009165 - The effect of synovial fluid proteins in the degradation of hyaluronic acid induced by ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  834     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Ceramides / metabolism
Epidermis / metabolism*
Fatty Acids, Essential / metabolism*
Fatty Acids, Unsaturated / metabolism
Linoleic Acid
Linoleic Acids / metabolism*
Lipoxygenase Inhibitors
Reg. No./Substance:
0/Arachidonic Acids; 0/Ceramides; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Lipoxygenase Inhibitors; 2197-37-7/Linoleic Acid; 26764-25-0/octadecadienoic acid; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaini...
Next Document:  Inhibitors of protein synthesis, puromycin and emetine, inhibit prostaglandin E2 release by skeletal...