Document Detail

Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat.
MedLine Citation:
PMID:  3922425     Owner:  NLM     Status:  MEDLINE    
Essential fatty acids are absolutely necessary for maintaining the proper condition of the water barrier (stratum compactum) in the skin. Even direct topical application of linoleic acid or any other Z,Z-(n-6, n-9)-fatty acid to the skin restores the barrier in essential fatty acid-deficient animals. In order to investigate the mechanism by which these polyunsaturated fatty acids exert their activity, radioactively labelled fatty acids were applied to the skin of the live animal and the epidermal lipids were analysed after 1-4 days. Much radioactivity was incorporated into two peculiar lipids, viz. acyl ceramide and acyl acid, which are characteristic of the barrier, in which linoleate was esterified to the end-position of very-long-chain (C30-34) unsaturated omega-hydroxy fatty acids. Strong evidence was obtained which showed that these lipids carry linoleate into the barrier layer where it is converted, probably by lipoxygenase(s), into a series of peroxidated lipids. The lipoxygenase inhibitor, eicosatetraynoic acid, prevents both oxygenation of the polyunsaturated fatty acid and the formation of a healthy skin. This peroxidation may supply the mediators which induce the proper differentiation of the epidermal cells into an effective stratum compactum and a horny layer.
D H Nugteren; E Christ-Hazelhof; A van der Beek; U M Houtsmuller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  834     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Ceramides / metabolism
Epidermis / metabolism*
Fatty Acids, Essential / metabolism*
Fatty Acids, Unsaturated / metabolism
Linoleic Acid
Linoleic Acids / metabolism*
Lipoxygenase Inhibitors
Reg. No./Substance:
0/Arachidonic Acids; 0/Ceramides; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Lipoxygenase Inhibitors; 2197-37-7/Linoleic Acid; 26764-25-0/octadecadienoic acid; 506-32-1/Arachidonic Acid

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