| Metabolism of inflammation limited by AMPK and pseudo-starvation. | |
| | |
MedLine Citation:
|
PMID: 23325217 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1α and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation. |
| | |
Authors:
|
Luke A J O'Neill; D Grahame Hardie |
Related Documents
:
|
22982107 - Cytoprotective effect of the small gtpase rhob expressed upon treatment of fibroblasts ... 21187437 - Pyk2 is required for neutrophil degranulation and host defense responses to bacterial i... 21278787 - Combined effects of novel heat shock protein 90 inhibitor nvp-auy922 and nilotinib in a... 11440177 - Modulation of human deoxycytidine kinase activity as a response to cellular stress indu... 18566587 - Essential function of torc2 in pkc and akt turn motif phosphorylation, maturation and s... 16322467 - The soluble extracellular domain of ephb4 (sephb4) antagonizes ephb4-ephrinb2 interacti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nature Volume: 493 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
|
Languages: eng Pagination: 346-55 Citation Subset: IM |
Affiliation:
|
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. laoneill@tcd.ie |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
//Cancer Research UK; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: mTOR is a key modulator of ageing and age-related disease.
Next Document: Fanconi anaemia and the repair of Watson and Crick DNA crosslinks.