Document Detail

Metabolism of inflammation limited by AMPK and pseudo-starvation.
MedLine Citation:
PMID:  23325217     Owner:  NLM     Status:  MEDLINE    
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1α and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
Luke A J O'Neill; D Grahame Hardie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  493     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-04     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  346-55     Citation Subset:  IM    
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MeSH Terms
AMP-Activated Protein Kinases / metabolism*
Anti-Inflammatory Agents / pharmacology
Dendritic Cells / cytology,  immunology
Glucose / metabolism
Inflammation / immunology,  metabolism*,  pathology
Macrophages / cytology,  immunology,  metabolism
Sirtuins / metabolism
Starvation / chemically induced,  metabolism*
T-Lymphocytes / immunology
Grant Support
097726//Wellcome Trust; //Cancer Research UK; //Wellcome Trust
Reg. No./Substance:
0/Anti-Inflammatory Agents; EC Protein Kinases; EC 3.5.1.-/Sirtuins; IY9XDZ35W2/Glucose

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