| Metabolism in rats of p-cymene derivatives: carvacrol and thymol. | |
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MedLine Citation:
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PMID: 2959918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolism of carvacrol and thymol in rats was studied using gas chromatographic-mass spectrometric methods. The urinary excretion of metabolites was rapid. Only very small amounts were excreted after 24 hrs. Although large quantities of carvacrol and, especially, thymol were excreted unchanged (or as their glucuronide and sulphate conjugates), extensive oxidation of the methyl and isopropyl groups also occurred. This resulted in the formation of derivatives of benzyl alcohol and 2-phenylpropanol and their corresponding carboxylic acids. In contrast, ring hydroxylation of the two phenols was a minor reaction. |
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Authors:
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L T Austgulen; E Solheim; R R Scheline |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 61 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-12-15 Completed Date: 1987-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 98-102 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, School of Medicine, University of Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Gas Chromatography-Mass Spectrometry Hydroxylation Male Monoterpenes* Rats Terpenes / metabolism*, urine Thymol / metabolism*, urine |
| Chemical | |
Reg. No./Substance:
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0/Monoterpenes; 0/Terpenes; 89-83-8/Thymol; 99-87-6/4-cymene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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