Document Detail


Metabolism in man of 7-ketolithocholic acid: precursor of cheno- and ursodeoxycholic acids.
MedLine Citation:
PMID:  7435569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To define the metabolism of 7-ketolithocholic acid in man, studies were carried out in gallstone patients with normal liver function. 7-[24-14C]ketolithocholic acid or its glycine or taurine conjugates were injected intravenously, and the chemical form of radioactivity appearing in bile was determined to define hepatic biotransformation. To study intestinal absorption 7-[24-14C]ketolithocholic acid was infused into the jejunum and ileum, respectively, and the chemical form of radioactivity appearing in peripheral blood and bile was assessed. 7-Ketolithocholic acid was extensively reduced in the liver to chenic acid and, to lesser extent, to ursodeoxycholic acid. Hepatic reduction was similar for both unconjugated as well as glycine- and taurine-conjugated 7-ketolithocholic acid. 7-Ketolithocholic acid was well absorbed. There was no biotransformation in the small intestinal lumen or during absorption, because all radioactivity recovered from the lumen or in peripheral blood was in unchanged 7-ketolithocholic acid. Biotransformation products in bile after jejunal infusion were similar to those after intravenous injection. The studies indicate that 7-ketolithocholic acid is likely to be a physiological precursor of ursodeoxycholic acid in healthy man.
Authors:
H Fromm; G L Carlson; A F Hofmann; S Farivar; P Amin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G161-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carbon Radioisotopes / diagnostic use
Female
Humans
Injections, Intravenous
Intestinal Absorption*
Intestine, Small / metabolism
Lithocholic Acid / administration & dosage,  analogs & derivatives*,  metabolism
Liver / metabolism*
Male
Middle Aged
Taurolithocholic Acid / administration & dosage,  metabolism*
Grant Support
ID/Acronym/Agency:
AM-16770/AM/NIADDK NIH HHS; AM-19689/AM/NIADDK NIH HHS; AM-21506/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 434-13-9/Lithocholic Acid; 4651-67-6/7-ketolithocholic acid; 516-90-5/Taurolithocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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