| Metabolism of the glutathione conjugate of propachlor by in situ perfused kidneys and livers of rats. | |
| | |
MedLine Citation:
|
PMID: 2346034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. [1-14C]Propachlor-GSH was perfused at 0.34, 3.4 and 34 mumol/h through the portal vein or the right renal artery of anaesthetized rats with biliary and ureteral cannulas. Urine was the predominant route for elimination of the 14C regardless of the route of perfusion. 2. Mercapturic acid conjugates were found to be the end-products of metabolism of the 14C-propachlor-GSH by rat kidneys and liver, indicating that all enzymes necessary for the catabolism of GSH conjugates to mercapturates were present in each of these tissues. 3. Perfusion of 14C-propachlor-GSH at 34 mumol/h appeared to exceed the metabolic capacity of both liver and kidneys for this substrate. At this dose, parent compound was detected in the bile of portally perfused rats, and the amounts of 14C recovered in bile, kidneys and carcasses of renally perfused rats were greater than when smaller dosages were perfused. |
| | |
Authors:
|
K L Davison; J E Bakke; G L Larsen |
Related Documents
:
|
3339874 - In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorou... 2859104 - Comparison of somatostatin-28 and somatostatin-14 clearance by the perfused rat liver. 20504724 - Modulation of [(3)h]noradrenaline release by endothelin-1 in the rat tail artery. 6789664 - Jejunal macromolecular absorption and bile salt deconjugation in protein-energy malnour... 3511734 - Role of renal nerves in rats with low-sodium, one-kidney hypertension. 17701484 - Primary study on transplantation of endothelialized dermal equivalents into normal rats. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 20 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1990 Apr |
Date Detail:
|
Created Date: 1990-06-29 Completed Date: 1990-06-29 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 375-83 Citation Subset: IM |
Affiliation:
|
USDA, ARS, Biosciences Research Laboratory, Fargo, ND 58105. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetanilides
/
metabolism* Acetylcysteine / metabolism, urine Animals Bile / metabolism Glutathione / metabolism* Herbicides / metabolism Kidney / metabolism Liver / metabolism Perfusion Rats Rats, Inbred Strains Xenobiotics / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Acetanilides; 0/Herbicides; 0/Xenobiotics; 1918-16-7/propachlor; 616-91-1/Acetylcysteine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microbiological transformation of flavone and isoflavone.
Next Document: Croconazole metabolism in rats.