Document Detail

Metabolism and functional roles of endogenous D-serine in mammalian brains.
MedLine Citation:
PMID:  16141516     Owner:  NLM     Status:  MEDLINE    
It has now been well established that D-serine, a coagonist for the N-methyl-D-aspartate (NMDA) glutamate receptors (NR1/NR2 type), is maintained at a high concentration in mammalian brains for life and shows a brain-selective and NMDA receptor R2B subunit-related distribution, overturning the hitherto generally accepted theory that D-amino acid is not always present in mammalian tissues. D-Serine in the brain has been shown to be contained in both the glia and neurons and to have specific processes of biosynthesis, extracellular release, uptake, and degradation. Moreover, the selective elimination of D-serine reduces the NMDA receptor-mediated intracellular signaling and long-term potentiation of synaptic connections. Together with the anti-psychotic and anti-ataxic property of D-serine and the pivotal roles of the NMDA receptor in divergent higher brain functions, these observations support the view that the D-amino acid may be involved as an endogenous modulator for the NMDA receptor in various neuropsychiatric functions and their pathological conditions.
Toru Nishikawa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  28     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-10-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1561-5     Citation Subset:  IM    
Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
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MeSH Terms
Brain / physiology*
Brain Chemistry / physiology*
Mental Disorders / drug therapy,  physiopathology
Nervous System Diseases / drug therapy,  physiopathology
Receptors, N-Methyl-D-Aspartate / agonists,  physiology
Serine / biosynthesis,  metabolism*,  physiology*
Reg. No./Substance:
0/Receptors, N-Methyl-D-Aspartate; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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