| Metabolism of fentiazac. | |
| | |
MedLine Citation:
|
PMID: 7192138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The main metabolite of 2-phenyl-4-p-chlorophenylthiazol-5-ylacetic acid (fentiazac) is represented by a p-hydroxylated compound which is formed rapidly and that, still 72 later, can be detected in the general circulation. The p-hydroxylated metabolite is much less toxic than the original molecule from which it derives, being still active from an anti-inflammatory standpoint (its activity being equal to 70--75% of that of fentiazac). The metabolite, which possesses a therapeutic index much higher than that of fentiazac, represents quite an important step in the detoxication processes of the drug and enhances the therapeutic activity of the drug itself. |
| | |
Authors:
|
S Fumero; A Mondino; S Silvestri; G Zanolo; G De Marchi; S Pedrazzini |
Related Documents
:
|
20080978 - Characterization of a novel type of oxidative decarboxylase involved in the biosynthesi... 378368 - Human urinary metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftoraful). 19157058 - The role of biotransformation and bioactivation in toxicity. 17045238 - The reaction of flavonoid metabolites with peroxynitrite. 21723178 - Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazole... 16624368 - Measurement of the initial phase of ozone decomposition in water and wastewater by mean... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Arzneimittel-Forschung Volume: 30 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1980 |
Date Detail:
|
Created Date: 1981-01-26 Completed Date: 1981-01-26 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 1253-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetic Acids
/
chemical synthesis,
metabolism* Animals Anti-Inflammatory Agents / chemical synthesis, metabolism* Biotransformation Chemistry, Physical Dogs Female Macaca fascicularis Male Physicochemical Phenomena Rats Thiazoles / chemical synthesis, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Acetic Acids; 0/Anti-Inflammatory Agents; 0/Thiazoles; 18046-21-4/fentiazac |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 1-Aroyl-5-nitrobenzotriazoles / 6th Communication: Antiinflammatory agents (author's transl)
Next Document: Characterization of a new potent heparin. 3rd Communication: Determinations of anticoagulant activit...