Document Detail


Metabolism of ethyl 4-aminobenzoate in the isolated single-pass perfused rabbit ear.
MedLine Citation:
PMID:  8198809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isolated rabbit ears were single-pass perfused with a protein-free Tris buffer solution. Ethyl 4-amino[U-ring-14C]benzoate or 4-amino[U-ring-14C]benzoic acid was applied to the epithelial surface in isopropyl myristate, or perfused arterially. Metabolites in the effusate were extracted and separated by high-performance liquid chromatography. Five metabolites were separated from ethyl aminobenzoate and identified as aminobenzoic acid, or acid-labile conjugates from either substrate. Their chemical structure has not yet been established. One metabolite, perhaps a glycolic acid N-conjugate of ethyl 4-aminobenzoate, was found at about 100 times higher concentration after arterial than after dermal drug application, indicating that the quantitative metabolic patterns in skin differ depending on whether the xenobiotic reaches the enzymes of the skin by cutaneous absorption or by the blood circulation. The metabolite pattern of the skin was compared with that from rabbit or rat liver cell preparations.
Authors:
B Henrikus; H G Kampffmeyer
Related Documents :
18964099 - A new method for the atomic-absorption determination of lead blended as lead alkyls in ...
15941309 - Pharmacokinetic study of caffeic and rosmarinic acids in rats after oral administration.
11528489 - Fatty acid absorption in preterms on formulas with and without long-chain polyunsaturat...
9145449 - Effects of short-chain fatty acids on gastrointestinal motility.
20414959 - Altered intestinal microbiota in irritable bowel syndrome.
3341259 - Inhibitory effect of nuts on iron absorption.
11032749 - Identification of a novel fibroblast growth factor, fgf-23, preferentially expressed in...
1590889 - Protective effects of phenolic compounds on ccl4-induced toxicity in isolated rat hepat...
21944859 - Synthesis and properties of novel 2'-o-alkoxymethyl-modified nucleic acids.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Skin pharmacology : the official journal of the Skin Pharmacology Society     Volume:  6     ISSN:  1011-0283     ISO Abbreviation:  Skin Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-07-01     Completed Date:  1994-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8810069     Medline TA:  Skin Pharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
Affiliation:
Walther-Staub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, München, BRD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Benzocaine / administration & dosage*,  metabolism*
Ear / physiology
Female
Injections, Subcutaneous
Liver / metabolism
Perfusion
Rabbits
Rats
Rats, Sprague-Dawley
Skin / metabolism*
Chemical
Reg. No./Substance:
94-09-7/Benzocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of inducers on the activity of glutathione S-transferase and other enzymes of the glutathione...
Next Document:  Increased superoxide anion production in dermal fibroblasts of psoriatic patients.