| Metabolism of ethyl 4-aminobenzoate in the isolated single-pass perfused rabbit ear. | |
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MedLine Citation:
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PMID: 8198809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated rabbit ears were single-pass perfused with a protein-free Tris buffer solution. Ethyl 4-amino[U-ring-14C]benzoate or 4-amino[U-ring-14C]benzoic acid was applied to the epithelial surface in isopropyl myristate, or perfused arterially. Metabolites in the effusate were extracted and separated by high-performance liquid chromatography. Five metabolites were separated from ethyl aminobenzoate and identified as aminobenzoic acid, or acid-labile conjugates from either substrate. Their chemical structure has not yet been established. One metabolite, perhaps a glycolic acid N-conjugate of ethyl 4-aminobenzoate, was found at about 100 times higher concentration after arterial than after dermal drug application, indicating that the quantitative metabolic patterns in skin differ depending on whether the xenobiotic reaches the enzymes of the skin by cutaneous absorption or by the blood circulation. The metabolite pattern of the skin was compared with that from rabbit or rat liver cell preparations. |
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Authors:
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B Henrikus; H G Kampffmeyer |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Skin pharmacology : the official journal of the Skin Pharmacology Society Volume: 6 ISSN: 1011-0283 ISO Abbreviation: Skin Pharmacol. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-07-01 Completed Date: 1994-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8810069 Medline TA: Skin Pharmacol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 246-52 Citation Subset: IM |
Affiliation:
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Walther-Staub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, München, BRD. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Benzocaine / administration & dosage*, metabolism* Ear / physiology Female Injections, Subcutaneous Liver / metabolism Perfusion Rabbits Rats Rats, Sprague-Dawley Skin / metabolism* |
| Chemical | |
Reg. No./Substance:
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94-09-7/Benzocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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