Document Detail

Metabolism of ethyl 4-aminobenzoate in the isolated single-pass perfused rabbit ear.
MedLine Citation:
PMID:  8198809     Owner:  NLM     Status:  MEDLINE    
Isolated rabbit ears were single-pass perfused with a protein-free Tris buffer solution. Ethyl 4-amino[U-ring-14C]benzoate or 4-amino[U-ring-14C]benzoic acid was applied to the epithelial surface in isopropyl myristate, or perfused arterially. Metabolites in the effusate were extracted and separated by high-performance liquid chromatography. Five metabolites were separated from ethyl aminobenzoate and identified as aminobenzoic acid, or acid-labile conjugates from either substrate. Their chemical structure has not yet been established. One metabolite, perhaps a glycolic acid N-conjugate of ethyl 4-aminobenzoate, was found at about 100 times higher concentration after arterial than after dermal drug application, indicating that the quantitative metabolic patterns in skin differ depending on whether the xenobiotic reaches the enzymes of the skin by cutaneous absorption or by the blood circulation. The metabolite pattern of the skin was compared with that from rabbit or rat liver cell preparations.
B Henrikus; H G Kampffmeyer
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Skin pharmacology : the official journal of the Skin Pharmacology Society     Volume:  6     ISSN:  1011-0283     ISO Abbreviation:  Skin Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-07-01     Completed Date:  1994-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8810069     Medline TA:  Skin Pharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
Walther-Staub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, München, BRD.
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MeSH Terms
Administration, Cutaneous
Benzocaine / administration & dosage*,  metabolism*
Ear / physiology
Injections, Subcutaneous
Liver / metabolism
Rats, Sprague-Dawley
Skin / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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