Document Detail

Metabolism and effects of organic compounds in animals.
MedLine Citation:
PMID:  2997977     Owner:  NLM     Status:  MEDLINE    
In recent years, society has become increasingly aware and concerned about protection from chemicals released into the environment. The knowledge of the metabolism and effects of organic compounds in animals, specifically food-producing animals, are of paramount importance in assessing potential human health hazards. An intensive effort has been directed at detection of chemicals in the environment, determination of their physiological insult and cellular interaction; in particular their carcinogenic and mutagenic induction capability. The chemical exposure of food-producing animals can be extremely difficult to evaluate and quite devastating. The exposure of food-producing animals to polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) emphasizes the seriousness of the problem. The polycyclic aromatic hydrocarbons (PAHs), capable of inducing cancer in experimental animals, have been studied extensively in laboratory animals. Current studies deal with the mechanism of metabolism of PAHs and the ultimate carcinogenic form. Although our knowledge concerning the health hazards of organic chemicals is continually increasing, its impact on food-producing animals and man's food chain is poorly understood. Awareness of the problem by practicing veterinarians and toxicologists, environmental toxicologists and public health officials is required to evaluate the impact of organic chemicals on the human food chain.
G R Eisele
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  27     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-16     Completed Date:  1985-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
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MeSH Terms
Animals, Domestic / metabolism*
Environmental Pollutants / metabolism*,  toxicity
Food Contamination
Polybrominated Biphenyls / metabolism,  toxicity
Polychlorinated Biphenyls / metabolism,  toxicity
Polycyclic Compounds / metabolism,  toxicity
Reg. No./Substance:
0/Environmental Pollutants; 0/Polybrominated Biphenyls; 0/Polychlorinated Biphenyls; 0/Polycyclic Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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