Document Detail


Metabolism of cortisol and cortisone in the baboon fetus at midgestation.
MedLine Citation:
PMID:  3335216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of cortisol (F) and cortisone (E) in the fetal circulation is likely to influence the availability/biological potency of these corticosteroids and hence maturation of fetal organ systems. Therefore, we determined the MCR, production, peripheral interconversion, and placental extraction of F and E in the baboon fetus at midgestation. Radiolabeled F and E were infused into a femoral vein of fetuses (n = 7; 4 female, 3 male) exteriorized on day 100 of gestation (term = day 184). The MCR of F in the fetus (5.6 +/- 0.8 1/day) was lower (P less than 0.01) than that of E (13.1 +/- 2.2 1/day). Placental extraction of F (72.8 +/- 5.3%) and E (87.8 +/- 2.4%) were extensive indicating that the placenta contributes to fetal F/E MCR. Although the serum concentration (micrograms per dl) of F (20 +/- 2) exceeded (P less than 0.01) that of E (12 +/- 1), the calculated production rate (milligrams per day) of F (1.09 +/- 0.12) was not significantly different from that of E (1.55 +/- 0.27). The transfer constant for fetal conversion of F to E (29.0 +/- 6.0%) exceeded (P less than 0.01) that for reduction of E to F (1.8 +/- 0.4%). Therefore, the proportion of total F production derived from circulating E was only 2.2%, whereas the proportion of E derived from circulating F was 26.7%. These findings demonstrate that at midgestation the baboon fetus has minimal capacity for peripheral conversion of biologically inactive E to biologically active F, whereas the reverse conversion (F to E) is substantial.
Authors:
B J Waddell; E D Albrecht; G J Pepe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  122     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-03     Completed Date:  1988-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Physiology, Eastern Virginia Medical School, Norfolk 23501.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cortisone / blood*
Female
Fetal Blood / metabolism
Fetus
Gestational Age
Hydrocortisone / blood*
Maternal-Fetal Exchange
Papio / blood*
Pregnancy
Grant Support
ID/Acronym/Agency:
HD-13294/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 53-06-5/Cortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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