Document Detail

Metabolism and biological activities of topical 4-oxoretinoids in mouse skin.
MedLine Citation:
PMID:  17943179     Owner:  NLM     Status:  MEDLINE    
Retinoic acid mediates most of the biological actions of vitamin A. It is oxidized by CYP26A1 to 4-oxoretinoic acid, considered as an inactive catabolite of retinoic acid. However, in the light of studies reporting the presence of 4-oxoretinal or 4-oxoretinol as the predominant retinoids during morphogenesis, we analyzed the retinoid-like biological activity of these oxoretinoids in mouse skin in vivo. Topical 4-oxoretinal and 4-oxoretinol promoted significant epidermal hyperplasia and metaplasia in mouse tail. They induced a moderate response for epidermal inflammation, compared with retinal, whereas neither 4-oxoretinal nor 4-oxoretinol prevented menadione-induced epidermal lipid peroxidation, unlike retinal and retinol. As analyzed by quantitative PCR, 4-oxoretinal and 4-oxoretinol did not reproduce the significant increased expression of genes coding for keratin 4, amphiregulin, heparin-EGF and CYP26A1, that did induce retinal and retinol. However, both retinal and 4-oxoretinal significantly inhibited the lipopolysaccharide-induced maturation of human dendritic cells in vitro. As analyzed in vivo and in vitro, 4-oxoretinal and 4-oxoretinol were not converted into retinoic acid. We conclude that 4-oxoretinal and 4-oxoretinol exert a moderate direct retinoid-like activity in vivo, thus confirming previous in vitro studies in amphibians showing 4-oxometabolites of vitamin A as bioactive agents rather than inactive catabolites.
Olivier Sorg; Christian Tran; Pierre Carraux; Denise Grand; Christelle Barraclough; Jean-François Arrighi; Patrick Descombes; Vincent Piguet; Jean-Hilaire Saurat
Related Documents :
14621139 - Boletus manicus heim.
17447159 - The effects of retinol on postprandial parameters in men with different fabp2 promoter ...
10485269 - All-trans retinoic acid at low concentration directly stimulates normal adult megakaryo...
271959 - Retinoic acid (vitamin a acid) induced transcriptional control of interferon production.
1056809 - Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic...
7720529 - Xenopus laevis: a model system for the study of embryonic retinoid metabolism. ii. embr...
12953219 - Studies on novel 7-acyl-5-chloro-2-oxo-3h-benzoxazole derivatives as potential analgesi...
20603199 - Ganoderic acid df, a new triterpenoid with aldose reductase inhibitory activity from th...
8828229 - Aspartate transport by the dct system in rhizobium leguminosarum negatively affects nit...
Publication Detail:
Type:  Journal Article     Date:  2007-10-18
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  128     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-13     Completed Date:  2008-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  999-1008     Citation Subset:  IM    
Department of Dermatology, University Hospital, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dendritic Cells / drug effects,  metabolism
Epidermis / drug effects,  metabolism,  pathology
Gene Expression / drug effects
Hyperplasia / chemically induced
Lipid Peroxidation / drug effects
Peroxidase / metabolism
Retinaldehyde / analogs & derivatives*,  chemistry,  metabolism,  pharmacology
Retinoids / pharmacology
Skin / drug effects*,  metabolism,  pathology
Vitamin A / analogs & derivatives*,  chemistry,  metabolism,  pharmacology
Reg. No./Substance:
0/Retinoids; 11103-57-4/Vitamin A; 116-31-4/Retinaldehyde; 33532-44-4/4-oxoretinaldehyde; 62702-55-0/4-oxoretinol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Human skin keloid fibroblasts display bioenergetics of cancer cells.
Next Document:  Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloi...