Document Detail

Metabolism of biogenic monoamines in the ciliated protozoan, Tetrahymena pyriformis.
MedLine Citation:
PMID:  7903622     Owner:  NLM     Status:  MEDLINE    
1. The three-dimensional HPLC system was used to detect the presence and determine the levels of biogenic monoamines, including precursor amino acids and metabolites, simultaneously in an extract of the ciliated protozoan, Tetrahymena pyriformis. 2. Representative biogenic monoamines, such as dopamine (DA), 5-hydroxytryptamine (5-HT), epinephrine (E) and kynurenine (KYN) were found to be synthesized in Tetrahymena and released into the growth medium. 3. The following metabolic pathways were suggested to be operative: (L-DOPA)-DA-(Epinine)-E-dihydroxyphenylethyleneglycol (DOPEG)-vanillylmandelic acid (VMA) and tyrosine-4 (TYR-4)-tyramine (TYRA)-hydroxyphenylacetic acid-4 (HPAC-4) in the case of catecholamines, and tryptophan (TRP)-5-HT and TRP-KYN-xanthurenic acid (XA) in the case of indolalkylamines. 4. As judged from the released metabolites, systems for generation of biogenic monoamines in Tetrahymena seem to be active during the logarithmic phase of its growth.
N Takeda; K Sugiyama
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  106     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-31     Completed Date:  1994-01-31     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Department of Biotechnology, COSMO Research Institute, Saitama, Japan.
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MeSH Terms
Biogenic Monoamines / metabolism*
Chromatography, High Pressure Liquid
Tetrahymena pyriformis / metabolism*
Reg. No./Substance:
0/Biogenic Monoamines

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