| Metabolism and biliary excretion of trimetrexate by the isolated perfused rat liver. | |
| | |
MedLine Citation:
|
PMID: 2933139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The metabolism and biliary excretion of trimetrexate (TMTX), a lipid soluble antifolate, were examined using a recirculating isolated perfused rat liver system. Elimination of TMTX into perfusate was biphasic and dose-independent, with distribution and elimination half-lives of 2 and 13 min. Two metabolites, M1 and M2, both known to inhibit dihydrofolate reductase activity, were present in perfusate only in small concentrations. However, of the total TMTX dose, approximately 50% was excreted in bile as M1, and 20% as M2. Up to 75% of the total dose was accounted for as TMTX, M1, or M2 in perfusate and bile. |
| | |
Authors:
|
L K Webster; W P Tong; J J McCormack |
Related Documents
:
|
3006849 - Rat plasma kallikrein clearance by perfused rat liver. 7125959 - The effect of repeated hemoperfusion over charcoal in the conscious rat on liver pathop... 7450399 - Effect of apolipoproteins on the induction of hepatic steatosis in rats. 9849619 - Oxygen consumption and biosynthetic function in perfused liver from rats at different s... 3591959 - In situ studies of distal convoluted tubule in rat. ii. k secretion. 9923539 - Pharmacokinetics of melphalan in isolated limb perfusion. 12802889 - Odor tracking in rats with orbital frontal lesions. 860639 - Comparative histological and histochemical studies on the adrenal gland of the albino a... 21663739 - β(2)-adrenergic activity of 6-methoxykaempferol-3-o-glucoside on rat uterus: in vitro ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cancer letters Volume: 29 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1985 Oct |
Date Detail:
|
Created Date: 1986-01-06 Completed Date: 1986-01-06 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 65-71 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / metabolism* Chromatography, High Pressure Liquid Folic Acid Antagonists / metabolism* Half-Life Kinetics Liver / metabolism* Male Perfusion Quinazolines / metabolism* Rats Rats, Inbred Strains Trimetrexate |
| Grant Support | |
ID/Acronym/Agency:
|
CA22435/CA/NCI NIH HHS; CA24543/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Folic Acid Antagonists; 0/Quinazolines; 52128-35-5/Trimetrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pilot study of intra-arterial floxuridine, mitomycin and doxorubicin in combination with degradable ...
Next Document: Selective toxicity of neocarzinostatin-monoclonal antibody conjugates to the antigen-bearing human m...