Document Detail


Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth.
MedLine Citation:
PMID:  22439618     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Consumption of anthocyanins has been related with beneficial health effects. However, bioavailability studies have shown low concentration of anthocyanins in plasma and urine. Phenolic compounds may be metabolized in the large intestine by gut microbiota. In this study, we have investigated the bacterial-dependent metabolism of malvidin-3-glucoside, gallic acid and a mixture of anthocyanins using a pH-controlled, stirred, batch-culture fermentation system reflective of the distall human large intestine conditions. Most anthocyanins have disappeared after 5 hours incubation while gallic acid remained constant through the first 5 hours and was almost completely degraded following 24 hours of fermentation. Incubation of malvidin-3-glucoside with faecal bacteria resulted mainly in the formation of syringic acid, while the mixture of anthocyanins resulted in formation of gallic, syringic and p-coumaric acids. All the anthocyanins tested enhanced significantly the growth of Bifidobacterium spp. and Lactobacillus - Enterococcus spp. Additionally, gallic acid decreased the number of Clostridium histolyticum group. and Bacteroides spp. These results suggest that anthocyanins and their metabolites may exert a positive modulation of the intestinal bacterial population.
Authors:
Maria Hidalgo; Maria Jose Oruna-Concha; Sofia Kolida; Gemma Emily Watson; Stamatina Kallithraka; Jeremy P E Spencer; Sonia de Pascual-Teresa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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