Document Detail

Metabolism of alpha-aminoisobutyric acid by soil bacteria.
MedLine Citation:
PMID:  4974389     Owner:  NLM     Status:  MEDLINE    
Eleven different bacteria, isolated by enrichment procedures on alpha-aminoisobutyric (AIB) as sole fixed nitrogen source, were examined for the mechanism by which they attacked the amino acid. All eleven organisms, including one which grew well on isopropylamine, converted AIB to acetone and CO(2) and showed an absolute dependence upon pyruvate for this reaction. No organism isolated degraded AIB to isopropylamine as the primary reaction. The data suggested that the usual mode of attack upon this amino acid is by an overall reaction comprised of two half reactions, one a decarboxylation-dependent transamination and the other a normal exchange transamination.
W B Dempsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  97     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1969 Jan 
Date Detail:
Created Date:  1969-03-21     Completed Date:  1969-03-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  182-5     Citation Subset:  IM    
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MeSH Terms
Acetone / biosynthesis
Aminoisobutyric Acids / metabolism*
Carbon Dioxide / metabolism
Carbon Isotopes
Nitrogen / metabolism
Pseudomonas aeruginosa / metabolism
Pyruvates / metabolism
Soil Microbiology*
Reg. No./Substance:
0/Aminoisobutyric Acids; 0/Carbon Isotopes; 0/Pyruvates; 124-38-9/Carbon Dioxide; 67-64-1/Acetone; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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