| Metabolism of administered triethylene tetramine dihydrochloride in humans. | |
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MedLine Citation:
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PMID: 9284083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triethylene tetramine dihydrochloride (trien 2HCl) has been used for the treatment of Wilson's disease, which is characterized by the accumulation of copper in various organs. We previously developed an HPLC system for analyzing trien, and found a trien metabolite in the urine when trien was orally given to humans. In this study, the metabolite was identified as 1-N-acetyltriethylene tetramine (acetyltrien) by FAB-MS and 1H-NMR spectroscopy. Trien and acetyltrien were capable of combining with copper, iron and zinc. However, the chelating activity of acetyltrien was significantly lower than that of trien. When trien was given to healthy adults, the amount of trien excreted in the urine was about 1% of the administered trien, whereas that of acetyltrien was about 8%. Most of the trien was excreted within the first 6 hours after the administration, while acetyltrien was excreted for over 26 hours. The urinary copper, iron and zinc levels all increased in parallel with the trien excretion. |
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Authors:
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H Kodama; Y Murata; T Iitsuka; T Abe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 61 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 899-907 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan. hkodama@med.teikyo-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Chelating Agents / metabolism*, pharmacology Chromatography, High Pressure Liquid Copper / metabolism, urine Female Humans Iron / metabolism, urine Magnetic Resonance Spectroscopy Male Spectrometry, Mass, Fast Atom Bombardment Triethylenetetramine / analogs & derivatives, metabolism*, pharmacology, urine Zinc / metabolism, urine |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 112-24-3/Triethylenetetramine; 7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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