Document Detail

Metabolism of acid mucopolysaccharides in hepatoma and in normal liver.
MedLine Citation:
PMID:  4376592     Owner:  NLM     Status:  MEDLINE    
The metabolism of acid mucopolysaccharides in Novikoff hepatoma and in hepatoma BW7756 was studied using the precursors -35S-sulfate, -H-glucosamine and -14C-galactosamine. There is an active formation of sulfated mucopolysaccharides at the mitochondria and cell membrane level. Hepatoma cells synthesize heparin to a lower rate than liver cells. In ascitic as well as in solid tumors there is a considerable accumulation of hyaluronic acid which does not seem to be elicited by the tumor cells but by the surrounding tissues. The possible implication of the low heparin production in the cell membrane characteristics is discussed.
L J Anghileri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology     Volume:  30     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  1974  
Date Detail:
Created Date:  1975-07-28     Completed Date:  1975-07-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  304-17     Citation Subset:  IM    
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MeSH Terms
Ascitic Fluid / cytology
Carcinoma, Hepatocellular / metabolism*
Cell Membrane / metabolism
Chondroitin / metabolism
Galactosamine / metabolism
Glucosamine / metabolism
Glycosaminoglycans / metabolism*
Heparin / biosynthesis
Hexosamines / isolation & purification
Hyaluronic Acid / metabolism
Liver / metabolism*,  ultrastructure
Liver Neoplasms / metabolism*
Mice, Inbred C57BL
Mitochondria, Liver / metabolism
Neoplasms, Experimental / metabolism
Sulfates / metabolism
Uronic Acids / isolation & purification
Reg. No./Substance:
0/Glycosaminoglycans; 0/Hexosamines; 0/Sulfates; 0/Uronic Acids; 3416-24-8/Glucosamine; 7535-00-4/Galactosamine; 9004-61-9/Hyaluronic Acid; 9005-49-6/Heparin; 9007-27-6/Chondroitin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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