| Metabolism of very-low-density lipoprotein and low-density lipoprotein containing apolipoprotein C-III and not other small apolipoproteins. | |
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MedLine Citation:
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PMID: 19910636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We aimed to clarify the influence of apolipoprotein C-III (apoCIII) on human apolipoprotein B metabolism. METHODS AND RESULTS: We studied the kinetics of 4 very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) types containing: (1) otherApos-CIII-: none of apoCIII, apoAII, apoCI, apoCII, or apoE; (2) otherApos+CIII-: no apoCIII but at least one of the others; (3) otherApos-CIII+: apoCIII, but not any others; and (4) otherApos+CIII+: apoCIII and at least one other. VLDL and IDL otherApos-CIII+ and otherApos-CIII- had similar rates of lipolytic conversion to smaller particles. However, light LDL otherApos-CIII+ compared with otherApos-CIII- had much faster conversion to dense LDL as did light LDL otherApos+CIII+ compared with otherApos+CIII-. VLDL and IDL otherApos-CIII+ had minimal direct removal from circulation, whereas VLDL and IDL otherApos+CIII-, rich in apoE, showed fast clearance. Lipoproteins in fraction otherApos+CIII+ also rich in apoE had very low clearance. CONCLUSIONS: The results suggest that apoCIII strongly inhibits hepatic uptake of VLDL and IDL overriding the opposite influence of apoE when both are present. The presence of apoCIII on dense VLDL is not associated with slow conversion to IDL, a lipoprotein lipase-dependent process; but when on light LDL, apoCIII is associated with enhanced conversion to dense LDL, a process involving hepatic lipase. |
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Authors:
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Carlos O Mendivil; Chunyu Zheng; Jeremy Furtado; Julian Lel; Frank M Sacks |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-12 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 30 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-02-17 Revised Date: 2011-10-24 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 239-45 Citation Subset: IM |
Affiliation:
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Harvard School of Public Health, Boston, Mass 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoprotein C-III / blood* Apolipoproteins B / blood Apolipoproteins E / blood Dietary Fats / administration & dosage, blood Female Humans Kinetics Lipase / metabolism Lipoprotein Lipase / metabolism Lipoproteins, IDL / blood Lipoproteins, LDL / blood* Lipoproteins, VLDL / blood* Liver / enzymology, metabolism* Male Middle Aged Models, Biological Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR002635-190572/RR/NCRR NIH HHS; P30 DK040561-14/DK/NIDDK NIH HHS; R01 HL-34980/HL/NHLBI NIH HHS; R01 HL-56210/HL/NHLBI NIH HHS; R01 HL056210-05/HL/NHLBI NIH HHS; R01 HL069376-04/HL/NHLBI NIH HHS; RR-02635/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-III; 0/Apolipoproteins B; 0/Apolipoproteins E; 0/Dietary Fats; 0/Lipoproteins, IDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; EC 3.1.1.3/Lipase; EC 3.1.1.3/hepatic lipase, human; EC 3.1.1.34/Lipoprotein Lipase |
| Comments/Corrections | |
Erratum In:
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Arterioscler Thromb Vasc Biol.2010 Sep;30(9):e171 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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