| Metabolism of a lipid nanoemulsion resembling low-density lipoprotein in patients with grade iii obesity. | |
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MedLine Citation:
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PMID: 20126342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Obesity increases triglyceride levels and decreases high-density lipoprotein concentrations in plasma. Artificial emulsions resembling lipidic plasma lipoprotein structures have been used to evaluate low-density lipoprotein metabolism. In grade III obesity, low density lipoprotein metabolism is poorly understood. OBJECTIVE: To evaluate the kinetics with which a cholesterol-rich emulsion (called a low-density emulsion) binds to low-density lipoprotein receptors in a group of patients with grade III obesity by the fractional clearance rate. METHODS: A low-density emulsion was labeled with [(14)C]-cholesterol ester and [(3)H]-triglycerides and injected intravenously into ten normolipidemic non-diabetic patients with grade III obesity [body mass index higher than 40 kg/m(2)] and into ten non-obese healthy controls. Blood samples were collected over 24 hours to determine the plasma decay curve and to calculate the fractional clearance rate. RESULTS: There was no difference regarding plasma levels of total cholesterol or low-density lipoprotein cholesterol between the two groups. The fractional clearance rate of triglycerides was 0.086 +/- 0.044 in the obese group and 0.122 +/- 0.026 in the controls (p = 0.040), and the fractional clearance rate of cholesterol ester (h(-1)) was 0.052 +/- 0.021 in the obese subjects and 0.058 +/- 0.015 (p = 0.971) in the controls. CONCLUSION: Grade III obese subjects exhibited normal low-density lipoprotein removal from plasma as tested by the nanoemulsion method, but triglyceride removal was slower. |
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Authors:
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Simone Alves Dantas; Elisabeth Salvatori Ficker; Carmen G C Vinagre; Barbara Maria Ianni; Raul Cavalcante Maranhão; Charles Mady |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics (São Paulo, Brazil) Volume: 65 ISSN: 1980-5322 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Affiliation:
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Unidade Clínica de Miocardiopatias - Instituto do Coração - Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo,São Paulo/SP,Brazil. si.dantas@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cholesterol, LDL / pharmacokinetics* Fat Emulsions, Intravenous / administration & dosage, chemistry, pharmacokinetics* Female Humans Male Middle Aged Nanoparticles* / administration & dosage Obesity / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Fat Emulsions, Intravenous |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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