Document Detail

Metabolism of L-cysteine in rats fed low and high protein diets.
MedLine Citation:
PMID:  6516897     Owner:  NLM     Status:  MEDLINE    
L-Cysteine (5.0 mmol per kg of body weight) was intraperitoneally injected into rats fed a 25% casein or 5% casein diet. Concentrations of acidic and neutral amino acids in various tissues were determined 2 h later. In the rats fed the 25% casein diet there was a tendency for tissue amino acid and glutathione levels to be slightly lower than controls. In the 5% casein diet group, however, concentrations of tissue amino acids and glutathione generally increased after L-cysteine administration. S-(2-Hydroxy-2-carboxyethylthio)cysteine (HCETC,3-mercaptolactate-cysteine disulfide), though in trace amounts, was detected in kidney and blood plasma in the 5% casein diet group. Increases in cysteine-glutathione disulfide in liver, kidney and erythrocytes in the 5% casein diet group were considerable. These results indicate that L-cysteine was rapidly metabolized in the 25% casein diet group through the oxidative pathway, while in the 5% casein diet group, in which liver cysteine dioxygenase activity is supposed to be quite low, the oxidative metabolism of L-cysteine decreased and part of the L-cysteine was metabolized through the transaminative pathway. Administration of 15.0 mmol L-cysteine per kg of body weight to rats fed the 25% casein diet resulted in an increase in cysteine-glutathione disulfide in liver, kidney and erythrocytes, and the appearance of HCETC in blood plasma.(ABSTRACT TRUNCATED AT 250 WORDS)
H Mikami; Y Hosaki; T Ubuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  38     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  415-21     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism
Caseins / administration & dosage,  metabolism
Cysteine / analogs & derivatives,  metabolism*
Cysteine Dioxygenase
Dietary Proteins / administration & dosage*,  metabolism
Glutathione / analogs & derivatives,  metabolism
Oxygenases / metabolism
Rats, Inbred Strains
Transaminases / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Caseins; 0/Dietary Proteins; 13081-14-6/cysteine-glutathione disulfide; 18841-42-4/beta-mercaptolactate cysteine disulfide; 52-90-4/Cysteine; 70-18-8/Glutathione; EC 1.13.-/Oxygenases; EC 1.13.11.-/Dioxygenases; EC Dioxygenase; EC 2.6.1.-/Transaminases

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