Document Detail


Metabolism, Distribution and Excretion of Deoxynivalenol with Combined Techniques of Radio-tracing, HPLC-IT-TOF/MS and Online Radiometric Detection.
MedLine Citation:
PMID:  24341775     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dispositions of deoxynivalenol (DON) in rats and chickens were investigated, using a radio tracer method in coupled with a novel γ-ARC radio-HPLC-IT-TOF-MS/MS system. 3β-3H-DON was chemically synthesized and orally administrated to both sexes of rats and chickens as a single or multiple doses. The results showed DON was widely distributed and quickly eliminated in all tissues. The highest concentration was found in gastro-intestinal tract at 6 h post-administration, substantially lower levels were detected in kidney, liver, heart, lung, spleen and brain. Three new metabolites were identified tentatively as 10-deoxynivalenol-sulfonate, 10-DOM-1-sulfonate and deoxynivalenol-3α-sulfate. Deoxynivalenol-3α-sulfate was a major metabolite in chickens, while the major forms in rats were DOM-1 and DON. Additionally, higher excretion rate in urine was observed in female rats than in male rats. The differences in metabolite profiles and excretion rates, which suggested diverse ways to detoxify, may relate to the different tolerance in different genders or species.
Authors:
Dan Wan; Lingli Huang; Yuanhu Pan; Qinghua Wu; Dongmei Chen; Yanfei Tao; Xu Wang; Zhenli Liu; Juan Li; Liye Wang; Zonghui Yuan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-16
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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