Document Detail

Metabolism of [6]-gingerol in rats.
MedLine Citation:
PMID:  12002808     Owner:  NLM     Status:  MEDLINE    
The metabolic fate of [6]-gingerol, one of the active constituents of Zingiber officinale Roscoe, was investigated using rats. The bile of rats orally administered [6]-gingerol was shown to contain a major metabolite (1) by HPLC analysis. Although the metabolites derived from [6]-gingerol were not detected in the urine, the ethyl acetate extract of the urine after enzymatic hydrolysis was shown to contain six minor metabolites (2-7). Their structures were determined to be (S)-[6]-gingerol-4'-O-beta-glucuronide (1), vanillic acid (2), ferulic acid (3), (S)-(+)-4-hydroxy-6-oxo-8-(4-hydroxy-3-methoxyphenyl) octanoic acid (4), 4-(4-hydroxy-3-methoxyphenyl)butanoic acid (5), 9-hydroxy [6]-gingerol (6) and (S)-(+)-[6]-gingerol (7) based on spectroscopic and chemical data. The total cumulative amount of 1 excreted in the bile and 2-7 in the urine during 60 h after the oral administration of [6]-gingerol were approximately 48% and 16% of the dose, respectively. The excretion of 2-7 in the urine decreased after gut sterilization. On the other hand, the incubations of [6]-gingerol with rat liver showed the presence of 9-hydroxy [6]-gingerol, gingerdiol (8), and (S)-[6]-gingerol-4'-O-beta-glucuronide (1). These findings suggest that the gut flora and enzymes in the liver play an important part in the metabolism of [6]-gingerol.
Takahiro Nakazawa; Keisuke Ohsawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  70     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-10     Completed Date:  2002-05-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2165-75     Citation Subset:  IM    
Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
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MeSH Terms
Administration, Oral
Bile / chemistry
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal*
Fatty Alcohols / administration & dosage,  pharmacokinetics*
Rats, Sprague-Dawley
Urine / chemistry
Reg. No./Substance:
0/Catechols; 0/Drugs, Chinese Herbal; 0/Fatty Alcohols; 1391-73-7/gingerol

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