| Metabolism of 6-aminonicotinic acid in Escherichia coli. | |
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MedLine Citation:
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PMID: 19420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide cycle. It is concluded that 6-aminonicotinamide and 6-aminonicotinic acid probably exert at least a portion of their bacteriostatic effects by being metabolized, by the enzymes of the pyridine nucleotide cycle, to 6-aminonicotinamide adenine dinucleotide and 6-aminonicotinamide adenine dinucleotide phosphate. These compounds are not electron acceptors and are known inhibitors of some pyridine nucleotide-linked dehydrogenases. |
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Authors:
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J R Cobb; S C Pearcy; R K Gholson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of bacteriology Volume: 131 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-10-20 Completed Date: 1977-10-20 Revised Date: 2010-08-31 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 789-94 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Escherichia coli
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metabolism* Mutation NAD / analogs & derivatives, biosynthesis NADP / analogs & derivatives, biosynthesis Niacinamide / analogs & derivatives, biosynthesis Nicotinic Acids / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nicotinic Acids; 53-59-8/NADP; 53-84-9/NAD; 98-92-0/Niacinamide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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