| Metabolism of 5'alpha,8'-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings. | |
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MedLine Citation:
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PMID: 14723955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We synthesized 5'alpha,8'-cycloabscisic acid (CycloABA), a highly potent and long-lasting abscisic acid (ABA) analogue, by a different method from that reported before. CycloABA fed to radish seedlings had more metabolic tolerance than ABA. The major metabolite of CycloABA was the glucose conjugate, which was the minor metabolite of ABA. The 8'-hydroxylated metabolite and its cyclized isomer, which were major metabolites of ABA, were not found as metabolites of CycloABA. The present results suggest that the highly potent and long-lasting activity of CycloABA is caused by resistance to ABA 8'-hydroxylase, and that CycloABA is partially metabolized to the glucose conjugate by ABA glucosyltransferase. |
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Authors:
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Yasushi Todoroki; Masao Sawada; Miyuki Matsumoto; Shigeko Tsukada; Kotomi Ueno; Masatoshi Isaka; Mariko Owaki; Nobuhiro Hirai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 12 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-15 Completed Date: 2004-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan. aytodor@agr.shizuoka.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abscisic Acid
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analogs & derivatives*,
metabolism*,
pharmacology Cytochrome P-450 Enzyme System / metabolism Germination / drug effects Mixed Function Oxygenases / metabolism Molecular Biology / methods Plant Growth Regulators / metabolism Raphanus / metabolism* Seedling / growth & development, metabolism Seeds / drug effects Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/5'alpha,8'-cycloabscisic acid; 0/Plant Growth Regulators; 21293-29-8/Abscisic Acid; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases; EC 1.14.99.-/abscisic acid 8'-hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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