| Metabolism of 3,3'-Diiodothyronine and 3'-monoiodothyronine, and effect of potassium cyanide and dinitrophenol and glucuronidation of thyroxine in cultured rat hepatoma cells. | |
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MedLine Citation:
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PMID: 7238420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat hepatoma cells (R117-21B) metabolized 3,3'diiodothyronine and 3'-monoiodothyronine by sulfation and glucuronidation. Glucuronidation of iodothyronines (a mixture of 3,3'-diiodothyronine, approximately 99%, and 3'-monoiodothyronine, approximately 10%(was very rapid and 83% of the total 125I in the medium was their glucuronides after 8 hr incubation with the cells at 37 degrees C. Iodothyronine sulfates (approximately 9% of the total 125I) were also detected. No clear increase in free iodide was observed during the 8 hr incubation. The effect of KCN or dinitrophenol on glucuronidation of thyroxine was investigated. Both drugs inhibited glucuronidation, and dinitrophenol was more effective than KCN. Dinitrophenol accelerated the liberation of 125I- in the metabolism of thyroxine in the cultured rat hepatoma cells. |
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Authors:
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K Sorimachi; A Niwa; Y Yasumura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinologia japonica Volume: 27 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 631-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Cyanides / pharmacology* Diiodothyronines / metabolism* Dinitrophenols / pharmacology* Glucuronates / metabolism Liver Neoplasms, Experimental / metabolism* Potassium Cyanide / pharmacology* Rats Thyronines / metabolism* Thyroxine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cyanides; 0/Diiodothyronines; 0/Dinitrophenols; 0/Glucuronates; 0/Thyronines; 151-50-8/Potassium Cyanide; 4732-82-5/3'-monoiodothyronine; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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