Document Detail


Metabolism of 15 (p 123I iodophenyl-)pentadecanoic acid in heart muscle and noncardiac tissues.
MedLine Citation:
PMID:  3987699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The uptake and turnover of omega(p 123I iodophenyl-)pentadecanoic acid (I-PPA), a radioiodinated free-fatty-acid analog, was examined in the heart, lung, liver, kidneys, spleen, and skeletal muscle of rats. At 2 min post injection, a high cardiac uptake of 4.4% dose per gram had already been achieved; this was followed by a rapid, two-component, tracer clearance. The kinetics of tissue concentrations of labeled hydrophilic catabolites indicated a rapid oxidation of I-PPA and the subsequent washout of I-PPA catabolites from heart-muscle tissue. The fractional distribution of the labeled cardiac lipids compared favorably with previously reported values for 3H-oleic- or 14C-palmitic-acid-labeled myocardial lipids. Typical patterns of I-PPA metabolism were observed in tissues depending on primary fatty-acid oxidation, lipid metabolism regulation, or I-PPA-catabolite excretion. The tissue concentrations and kinetics of I-PPA and its metabolites in the heart muscle indicated that general pathways of cardiac-lipid metabolism are traced by this new gamma-emitting isotope-labeled radiopharmaceutical.
Authors:
S N Reske; W Sauer; H J Machulla; J Knust; C Winkler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  10     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-10     Completed Date:  1985-06-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Iodine Radioisotopes
Iodobenzenes / metabolism*
Kinetics
Male
Myocardium / metabolism*
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Iodobenzenes; 80479-93-2/omega-(4-iodophenyl)pentadecanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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