Document Detail

Metabolic and ventilatory responses to CO hypoxia at different levels of oxygenation in the rat.
MedLine Citation:
PMID:  11788134     Owner:  NLM     Status:  MEDLINE    
Adult, conscious rats have been exposed to CO-induced hypoxia for 30 min in normoxia, ambient hypoxia (FI(O(2))=14%), or hyperoxia (FI(O(2))=40%). From arterial blood gas analyses, FICO was adjusted in all experimental conditions to obtain final arterial oxygen saturations (Sa(O(2))) of approximately 60%. Oxygen uptake (V(O(2))), ventilation (V) and colonic temperature (Tc) were measured in experiments carried out at an ambient temperature of either 25 or 15 degrees C. It was found that CO hypoxia induced marked reductions in the hemoglobin O(2) half saturation pressure (P(50)). Furthermore, isolated reductions in Sa(O(2)) (with Pa(O(2)) constant) induced decreases in V(O(2)) and Tc and increases in ventilation which, as compared with normoxia, were enhanced in ambient hypoxia and reduced but still significant in hyperoxia. As suggested by previous studies, the interactions between Sa(O(2)) and Pa(O(2)) which operate on the control of metabolism and ventilation originate probably in the central nervous system.
Henry Gautier; Cristina Murariu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  129     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-14     Completed Date:  2002-03-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  307-15     Citation Subset:  IM    
Atelier de Physiologie Respiratoire, Faculté de Médecine Saint-Antoine, 27, rue Chaligny, 75012 Paris, France.
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MeSH Terms
Anoxia / blood,  chemically induced*,  physiopathology*
Body Temperature
Carbon Dioxide / blood
Carbon Monoxide*
Oxygen / blood*
Oxygen Consumption
Partial Pressure
Rats, Wistar
Reg. No./Substance:
124-38-9/Carbon Dioxide; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen

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