| Metabolic tumor volumes by [18F]-fluorodeoxyglucose PET/CT correlate with occult metastasis in oral squamous cell carcinoma of the tongue. | |
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MedLine Citation:
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PMID: 19609618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the correlation between pretreatment metabolic tumor volume (MTV) as determined by [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and occult metastasis (OM) in oral squamous cell carcinoma (OSCC) of the tongue. METHODS: Forty-three clinically node-negative (cN0) OSCC patients, diagnosed by preoperative workups (biopsy, physical examination, CT, and PET/CT) were enrolled. All patients had undergone primary tumor resections and elective neck dissections. MTVs were measured for tumors showing standardized uptake value (SUV) of >2.5 by an automated contouring program. Pretreatment variables (age, sex, clinical T stage, maximal SUV [SUV(max)] and MTV) and posttreatment variables (pathologic T stage, depth of invasion, lymphovascular invasion, pathologic tumor volume, and histological differentiation) were analyzed to identify their correlation with OM. RESULTS: Twelve (27.9%) of 43 patients were found to have OM in pathologic specimen of neck dissections. A cutoff of 6.0 ml for the MTV was determined to be the most discriminative value for predicting OM. By univariate analysis, the patients with an MTV of >6.0 ml had significantly higher number of occult metastases than those with an MTV of <or=6.0 ml (57.1% vs. 13.7%, hazard ratio 8.33, 95% confidence interval, 1.95-35.6, P=0.009). Lymphovascular invasion and SUV(max) showed only trends toward significance (P=0.08 and 0.05, respectively). By multivariate analysis, only MTV had a significant correlation with OM (hazard ratio 54.66, 95% confidence interval, 1.05-2842.86, P=0.04). CONCLUSIONS: MTV as determined by PET/CT demonstrated a statistically significant correlation with OM in patients with cN0 OSCC of the tongue. |
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Authors:
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Man Ki Chung; Han-Sin Jeong; Young-Ik Son; Yoon Kyoung So; Ga Young Park; Joon Young Choi; Seung Hyup Hyun; Hyung-Jin Kim; Young-Hyeh Ko; Chung-Hwan Baek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-16 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 16 ISSN: 1534-4681 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 3111-7 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Squamous Cell / diagnosis*, secondary, surgery Female Fluorodeoxyglucose F18 / diagnostic use* Humans Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local / diagnosis, surgery Neoplasm Staging Positron-Emission Tomography* Prognosis Radiopharmaceuticals / diagnostic use* Survival Rate Tomography, X-Ray Computed* Tongue Neoplasms / diagnosis*, surgery Treatment Outcome Tumor Burden Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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