| Metabolic syndromes and malignant transformation: where the twain shall meet. | |
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MedLine Citation:
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PMID: 20962328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrent somatic mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes that result in the accumulation of D-2-hydroxyglutarate (D-2-HG) have been identified in malignant gliomas and in acute myeloid leukemia (AML). However, the function of this metabolite in normal and malignant tissues remains uncertain. A report in the current issue of Science describes a germline IDH2 mutation in a subset of patients with a rare metabolic disorder--D-2-hydroxyglutaric aciduria-that is similar to mutations seen in cancer patients. These observations further elucidate the effects of IDH mutations on normal and malignant cells. |
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Authors:
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Neha Bhagwat; Ross L Levine |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 54ps50 Citation Subset: IM |
Affiliation:
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Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Transformation, Neoplastic* Glioma / complications*, metabolism, pathology Glutarates / metabolism* Humans Isocitrate Dehydrogenase / genetics, metabolism Leukemia, Myeloid, Acute / complications*, metabolism, pathology Metabolism, Inborn Errors / complications*, metabolism, pathology Mutation |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Glutarates; 2889-31-8/alpha-hydroxyglutarate; EC 1.1.1.41/Isocitrate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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