| Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients. | |
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MedLine Citation:
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PMID: 22272071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events. OBJECTIVE: We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function. METHODS: We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria. RESULTS: Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = -0.223, P = 0.03) and fasting blood glucose (r = -0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD. CONCLUSION: MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients. |
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Authors:
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Qiong Bai; Xuan Lai; Ai-Hua Zhang; Xin-Hong Lu; Shun-Li Tian; Min-Hua Fan; Yue Wang; Tao Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-06 |
Journal Detail:
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Title: Vascular health and risk management Volume: 8 ISSN: 1178-2048 ISO Abbreviation: Vasc Health Risk Manag Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: 2012-10-05 Revised Date: 2013-03-01 |
Medline Journal Info:
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Nlm Unique ID: 101273479 Medline TA: Vasc Health Risk Manag Country: New Zealand |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Glucose / metabolism Brachial Artery / physiopathology Cross-Sectional Studies Endothelium, Vascular / physiopathology* Female Glomerular Filtration Rate Humans Kidney Failure, Chronic / complications, physiopathology* Linear Models Male Metabolic Syndrome X / complications, physiopathology* Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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