Document Detail

Metabolic syndrome and its components associated with endothelial dysfunction in chronic kidney disease patients.
MedLine Citation:
PMID:  22272071     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiovascular disease is more common in patients with chronic kidney disease (CKD) than in the general population. Endothelial dysfunction is an early predictor of cardiovascular events.
OBJECTIVE: We conducted a cross-sectional study in CKD patients to explore the association of metabolic syndrome (MetS) components with endothelial cell function.
METHODS: We evaluated clinical and laboratory data in 161 CKD patients from stage 1 to stage 5. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III criteria.
RESULTS: Patients were grouped into two groups according to whether or not they had MetS. FMD was significantly lower in the MetS group than in the group without MetS (P = 0.012). In a Pearson's correlation analysis, FMD was significantly negatively correlated with waist circumference in women (r = -0.223, P = 0.03) and fasting blood glucose (r = -0.186, P = 0.001). Multiple linear regression analysis showed that fasting blood glucose was an independently associated factor for FMD.
CONCLUSION: MetS and some components of MetS (waist circumference in women and fasting blood glucose) are closely associated with a decreased FMD in CKD patients.
Qiong Bai; Xuan Lai; Ai-Hua Zhang; Xin-Hong Lu; Shun-Li Tian; Min-Hua Fan; Yue Wang; Tao Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-06
Journal Detail:
Title:  Vascular health and risk management     Volume:  8     ISSN:  1178-2048     ISO Abbreviation:  Vasc Health Risk Manag     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-10-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101273479     Medline TA:  Vasc Health Risk Manag     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Division of Nephrology, Peking University Third Hospital, Beijing, People's Republic of China.
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MeSH Terms
Aged, 80 and over
Blood Glucose / metabolism
Brachial Artery / physiopathology
Cross-Sectional Studies
Endothelium, Vascular / physiopathology*
Glomerular Filtration Rate
Kidney Failure, Chronic / complications,  physiopathology*
Linear Models
Metabolic Syndrome X / complications,  physiopathology*
Middle Aged
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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